Different cerebral cortical areas influence the effect of subthalamic nucleus stimulation on parkinsonian motor deficits and freezing of gait
Identifieur interne : 001074 ( Main/Exploration ); précédent : 001073; suivant : 001075Different cerebral cortical areas influence the effect of subthalamic nucleus stimulation on parkinsonian motor deficits and freezing of gait
Auteurs : Chul Hyoung Lyoo [Corée du Sud] ; Sargo Aalto [Finlande] ; Juha O. Rinne [Finlande] ; Ki Ook Lee [Corée du Sud] ; Seung Hun Oh [Corée du Sud] ; Jin Woo Chang [Corée du Sud] ; Myung Sik Lee [Corée du Sud]Source :
- Movement Disorders [ 0885-3185 ] ; 2007-11-15.
English descriptors
Abstract
Inconsistent response in freezing of gait (FOG) with levodopa treatment or STN DBS makes the pathogenesis difficult to understand. We studied brain areas associated with the expression of STN DBS effect on parkinsonian motor deficits and FOG. Ten Parkinson's disease patients with typical FOG were included. One month before STN DBS, we performed [18F]‐deoxyglucose PET scans and measured the UPDRS motor and modified FOG (mFOG) scores during levodopa off and on periods. At two months after STN DBS, same rating scores were measured. The percentage improvement of mFOG and UPDRS motor scores by STN DBS during levodopa off period was calculated. We searched for brain areas in which glucose metabolism correlated with the improvement of mFOG and UPDRS motor scores by DBS. During levodopa off period, STN DBS improved the UPDRS motor scores by 32.3% and the mFOG scores by 56.6%. There was no correlation between the improvements of both scores. The improvement of UPDRS motor score by DBS correlated with the metabolic activities of rostral supplementary motor area (Brodmann's area 8; BA8), anterior cingulate cortex (BA32), and prefrontal cortex (BA9). On the other hand, there was a positive correlation between the improvement of mFOG score by DBS and the metabolic activity of the parietal, occipital, and temporal sensory association cortices. In conclusion, dysfunction of different cerebral cortical areas limits the beneficial effects of DBS on parkinsonian motor deficits and FOG. © 2007 Movement Disorder Society
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DOI: 10.1002/mds.21609
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2007-11-15">2007-11-15</date><biblScope unit="volume">22</biblScope><biblScope unit="issue">15</biblScope><biblScope unit="page" from="2176">2176</biblScope><biblScope unit="page" to="2182">2182</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">48AA5A22FC01E51F248E9F9A02062C4D3D8EE63B</idno><idno type="DOI">10.1002/mds.21609</idno><idno type="ArticleID">MDS21609</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>deep brain stimulation</term><term>gait freezing</term><term>positron emission tomography</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Inconsistent response in freezing of gait (FOG) with levodopa treatment or STN DBS makes the pathogenesis difficult to understand. We studied brain areas associated with the expression of STN DBS effect on parkinsonian motor deficits and FOG. Ten Parkinson's disease patients with typical FOG were included. One month before STN DBS, we performed [18F]‐deoxyglucose PET scans and measured the UPDRS motor and modified FOG (mFOG) scores during levodopa off and on periods. At two months after STN DBS, same rating scores were measured. The percentage improvement of mFOG and UPDRS motor scores by STN DBS during levodopa off period was calculated. We searched for brain areas in which glucose metabolism correlated with the improvement of mFOG and UPDRS motor scores by DBS. During levodopa off period, STN DBS improved the UPDRS motor scores by 32.3% and the mFOG scores by 56.6%. There was no correlation between the improvements of both scores. The improvement of UPDRS motor score by DBS correlated with the metabolic activities of rostral supplementary motor area (Brodmann's area 8; BA8), anterior cingulate cortex (BA32), and prefrontal cortex (BA9). On the other hand, there was a positive correlation between the improvement of mFOG score by DBS and the metabolic activity of the parietal, occipital, and temporal sensory association cortices. In conclusion, dysfunction of different cerebral cortical areas limits the beneficial effects of DBS on parkinsonian motor deficits and FOG. © 2007 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Corée du Sud</li><li>Finlande</li></country><region><li>Finlande occidentale</li></region><settlement><li>Séoul</li><li>Turku</li></settlement><orgName><li>Université de Turku</li></orgName></list><tree><country name="Corée du Sud"><noRegion><name sortKey="Lyoo, Chul Hyoung" sort="Lyoo, Chul Hyoung" uniqKey="Lyoo C" first="Chul Hyoung" last="Lyoo">Chul Hyoung Lyoo</name></noRegion><name sortKey="Chang, Jin Woo" sort="Chang, Jin Woo" uniqKey="Chang J" first="Jin Woo" last="Chang">Jin Woo Chang</name><name sortKey="Lee, Ki Ook" sort="Lee, Ki Ook" uniqKey="Lee K" first="Ki Ook" last="Lee">Ki Ook Lee</name><name sortKey="Lee, Myung Sik" sort="Lee, Myung Sik" uniqKey="Lee M" first="Myung Sik" last="Lee">Myung Sik Lee</name><name sortKey="Oh, Seung Hun" sort="Oh, Seung Hun" uniqKey="Oh S" first="Seung Hun" last="Oh">Seung Hun Oh</name></country><country name="Finlande"><region name="Finlande occidentale"><name sortKey="Aalto, Sargo" sort="Aalto, Sargo" uniqKey="Aalto S" first="Sargo" last="Aalto">Sargo Aalto</name></region><name sortKey="Rinne, Juha O" sort="Rinne, Juha O" uniqKey="Rinne J" first="Juha O" last="Rinne">Juha O. 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